The PLAT Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PLAT, and TPA. This antibody recognizes Human, Mouse, and Rat antigen. The PLAT Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms